EPHA10

A10 is EPH receptor protein of human encoded by EPHA10 gene. Most of the subfamily (RTK) receptor tyrosine kinase ephrin receptors, communication and control of cell adhesion between cells, and ephrin ligands thereof, is an important mediator of mobility and shape of neuroepithelial cells. Please refer to the MIM 179610 background Eph receptor and ephrin further order. Most of the subfamily (RTK) receptor tyrosine kinase ephrin receptor and ephrin ligands thereof, moves and shape of 179 610 cells.See MIM epithelial and nerve cells for communication control of cell during cell adhesion Eph receptor is an important mediator of resistance and background of ephrin added.

It is identified to date in Ephesus subfamily, represents the largest group of receptor protein tyrosine kinase. Not yet biological activity of these receptors is to be defined, although these have grown evidence that are involved in the development of central nervous system function. Eph receptor subfamily of human origin are included EphB6 of EphA6, EphA7, of EphA8, EphB1, EPHB2, EphB3, EphB4, of EphA3, EphA4, the EphA1, EphA2, EphA5 is, and EphB5. Ligand of the receptor of Ephesus is the ephrin-A4, which connects the EphB1 and EphA3. In addition, ephrin-A2 is described as a ligand for ephrin-A3, EphA4 as ephrin-B2 ligand and of the EphA5 as a ligand for EphB4.

It is affected by chemodirectants containing receptor tyrosine kinases large family called EPHS collectively cell migration. EPHS is divided into two classes based on the specificity and structure of the extracellular ligand. Eph receptor that preferentially binds to ephrin ligand is referred to as EPHA. Eph receptors all contain an extracellular domain consisting of globular domain, cysteine-rich domain, from two fibronectin type III domain. This is followed by a cytoplasmic domain and the transmembrane region. The cytoplasmic domain, juxtamembrane motif and motif that is stored in the carboxy tail tyrosine residues with two tyrosine residues conservative, kinase domain, and sterilization contains.

The Eph receptors, most of the ephrin ligand family of receptor tyrosine kinases are important intercellular communication that regulate the mobility and the shape of the endothelial cells and neural function cell adhesion, and development of the central nervous system mediators. EPHB and EPHA: Eph receptors, can be divided into two sub-groups. In mammals, class EPHA General ephrin – are made up of eight members that are connected to the member that is associated with the cell membrane by Glico link. The ephrin-B member, EPHB class consists 6 members tend to be linked across the cytoplasmic membrane of (EPHB 1-6),. Ephrin / EPH is embryonic development, signaling network WNT signaling pathway between carcinogenesis and tissue regeneration. A recent study Effects / EFN is important in B-cell biology of normal, it may represent a therapeutic target and prognostic markers novel potential CLL is shown.

In mammals, the members 14 of the Eph family of receptor tyrosine kinases have been described so far. Members that are not listed here yet of this family showed EphA10. Through two isoforms and soluble: We report the identification of EphA10 isoforms estimation of the following three. One of the two isoforms of these lacking the sterile motif found in Ephesians receptor often. EphA10 mRNA, which is located in the gene expression studies EphA10 that encode the chromosome 1p34 shows that it is expressed primarily in the testis. The receptor, binding studies of ephrin ligand, suggesting that they belong to a subclass of Eph receptor ligand ephrin EPHA binder mainly.