Protein encoded by the EPHA6 gene.We in humans by using the genome of their own and public, in addition to (the “buds” above) protein kinase of the human genome, ephrin receptor 6, complementary it is cataloged sequence tags and DNA (expressed EST) sequence. As a starting point for a comprehensive analysis of protein phosphorylation in disease states and normal, we focus on the gene family of large-scale, It provides a detailed picture of the current state of genomic analysis of human. Were reported, of which 71 such kinases have been disclosed, and are not adjusted or extended protein sequence of the kinase of 56 or more, we have identified 518 putative protein kinase genes. Family previously unknown, some of which family members are stored in the model organism new gene is well studied, but is included. Compared with the classification of model organisms to identify ortholog groups, emphasis kinomes deployment specific to the line of humans and other. We also, I have identified 106 protein kinase pseudogenes. The mapping of chromosomes, a small group of several kinase gene revealed 244 kinase revealed that mapping cancer or amplicon disease locus.
In the contact-dependent bidirectional signaling device to adjacent cells, and as a result, random GPI-anchored ephrin present in the cell in the adjacent – receptor tyrosine kinase that binds the family ligand. Signaling pathway of the ligand ephrin signal while called reverse, downstream, downstream signaling first, the signaling path of the receptor
EPHA6 members, axon guidance, neuron – is the ephrin receptor subfamily of protein tyrosine kinases that are involved in synaptic function in the region of fragmentation nervous system and target interaction. EPHA6 is expressed in the testis and advanced brain. Common defects that affect the development and closure hypospadias, the external genitalia were observed reduction EPHA6. EPHA6 genetic inhibition of mouse produces behavioral disorders of learning and memory, the specific validation. Mice deficient in EPHA6 show, reduced the memory effect of the training context.
A contact-dependent bidirectional device in neighboring cells, resulting in random GPI-anchored ephrin present in the cell adjacent – EphA6 receptor tyrosine kinases bind to the family ligand. Downstream between signaling pathways ligand ephrin reverse signaling is called downstream signaling the first signaling path of the receptor. It belongs to a superfamily of protein kinases. Tyrosine protein kinase family. Ephrin receptor subfamily. 2 isoform of the human protein produced by alternative splicing. Note: This description may include information from UniProtKB.
Ephrin type also EHK-2 and 2, Epha6 EPH kinase same sex, I membrane protein belonging to the superfamily of ephrin receptor subfamily and single-pass protein kinase, 6, which is known as a receptor. It involves a (sterile motif) domain fibronectin type III domain of one 2, SAM and the protein kinase domain. EphA6 is involved in neural circuits Eph receptors other and with the number of ephrin ligands thereof, related to aspects of learning and memory. The EPHA1, EphA2, of EPHA3, EphA4, is EphA5, of EPHA6, EphA7, EPHA8, EPHA10, EPHB1, EPHB2, EPHB3, EphB4 Noto EPHB6 is ephrin family of Eph receptor family ligand. The signaling network WNT signaling pathways during carcinogenesis of ephrin / EPH embryonic development, and tissue regeneration. In molecular biology, Eph receptors and ephrins are components of cellular signaling pathways involved in the development of animals, and is involved in certain cancers. Eph receptors form a RTK subfamily and the largest, are classified as receptor tyrosine kinases. Eph receptors All are expressed at the stage of well-defined different concentrations and development in various positions most of the time.
It is affected by chemodirectants containing receptor tyrosine kinases large family called EPHS collectively cell migration. EPHS is divided into two classes based on the specificity and structure of the extracellular ligand. Eph receptor that preferentially binds to ephrin ligand is referred to as EPHA. Eph receptors all contain an extracellular domain consisting of globular domain, cysteine-rich domain, from two fibronectin type III domain. This is followed by a cytoplasmic domain and the transmembrane region. Tyrosine residue of two juxtamembrane motif and kinase domain are included, cytoplasmic domain continued to (SAM) sterile alpha motif at the carboxy tail and tyrosine residues conservative.