Integrin α-V is a protein encoded by a gene ITGAV in humans. The V. integrin encoding the integrin alpha chain, ITAGV is a heterodimer integral membrane protein comprising one α and β chain from chain. To form the different integrins, αV undergoes posttranslational cleavage in order to obtain heavy and light chain disulfide bond is coupled a plurality of integrin β chains. , Association β chains, respectively, αV, known that can interact with ligands of the extracellular matrix of 1,3-chain “ITGB8” β and (“ITGB1”, “ITGB3”, “ITGB5”, “ITGB6” , out of eight) 5, 6, and probably β3 integrin, most of those studies, vitronectin receptor is (VNR). That in addition to the adhesive, to promote integrin signaling many are known.
This gene encodes a protein that is a member of the integrin superfamily. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. To form the different integrins, the protein undergoes post-translational cleavage in order to obtain heavy and light chain disulfide bond joining the integrin β chains plurality. Is shown β-1, 3 heterodimeric β, β5, β6, FIG 8 and β, the heterodimer of β and α V 3, the protein is a vitronectin receptor. This protein interacts with extracellular matrix proteins of several that mediate cell adhesion involved in cell migration. It should be noted that this protein regulates the progression of cancer and angiogenesis has been suggested. In many embodiments of the transcripts encoding the protein isoforms different, as a result of alternative splicing.
It is an important step in the metastatic cascade, binding of cancer cells to vascular endothelium is mediated by integrins. Romanov Goligorsky prostate cancer cell interleukin-1 from the umbilical vein (the HUVEC) – using phage display to identify integrin is an important mediator of adhesion of human endothelial cells stimulated. Adhesion mediated PC-3, along with α3β1 and α5β1, these data, DU145 when suggesting that αVβ3 the HUVEC monolayer. In another study, stimulated by (S) eicosanoids 12 illustrates the murine melanoma cell adhesion microvascular endothelial cells – hydroxy-eicosatetraenoic acid is carried out by the αvβ3 integrin. Prostate cancer, for but often spreads to the bones, Romanov Goligorsky are using HUVEC, the importance of research of prostate cancer clinical has been questioned. Further, the prostate cancer cell lines, the HUVEC, preferably adhered to the human bone marrow endothelial cells has been shown. Αvβ3 integrin may be important for adhesion of prostate cancer cells HUVEC, but plays a role in adhesion of prostate cancer bone marrow endothelial This integrin is determined.
By adhesion and migration to the prostate cancer cell components present in the bone matrix during the integrin αvβ3, is conducted under particular. DU145 was reduced cell adhesion to the crude extract from bone protein of 94% well-characterized antibodies against (LM609) integrin αvβ3. Protein structure of the protein of the bone of the crude extracts has not been determined but, vitronectin and osteopontin is a protein common to ligands suitable for αvβ3 and mature bone. And Cheng. I show that the migration of osteopontin and vitronectin and PC-3 cell adhesion is dependent αvβ3 integrin. LNCaP cells do not migrate to osteopontin and vitronectin or stick to, because they do not express this integrin. The adhesion to vitronectin mediation, exogenous expression of integrin αvβ3 not osteopontin the LNCaP cells. LNCaP cells was, amazing Witkowski et al was used in the study. and expressed the αVβ3, but these cells do not conform to vitronectin, suggesting that monomer of this integrin is not functionally active. LNCaP cell adhesion to osteopontin is not evaluated in this study.
The V. integrin encoding the integrin alpha chain, ITAGV is a heterodimer integral membrane protein comprising one α and β chain from chain. I-domain containing integrin V is obtained subject to posttranslational cleavage
To form the integrin different disulfide-bonded, light chain and heavy chain binding to the integrin β chains plurality. , Association β chains, respectively, αV, known that can interact with ligands of the extracellular matrix of 1,3-chain “ITGB8” β and (“ITGB1”, “ITGB3”, “ITGB5”, “ITGB6” , out of eight) 5, 6, and probably β3 integrin, most of those studies, vitronectin receptor is (VNR). That in addition to the adhesive, to promote integrin signaling many are known. Result of alternative splicing in the transfer multiple variants.
Integrin α V is the receptor for vWF vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase -2, osteopontin osteomodulin, prothrombin, and thrombospondin. They recognize the RGD sequence in a wide range of ligands. In the case of HIV-1 infection, it appears interactions with extracellular viral Tat protein to enhance angiogenesis in Kaposi’s sarcoma lesions
hetero β subunit and α. α subunit is composed of a light chain and a binding heavy chain by a disulfide bond. fellow of α and V β-subunit 8 or β-1, P-3, P-5 ,6-β. I reacted with Tat of HIV-1. It is associated with a function as a receptor for virus Alpha-V/beta-6 hoof mouth virus (FMDV) and VP1 protein. It is associated with a function as a receptor of these viruses and B1 capsid protein and coxsackievirus Alpha-V/beta-6 Coxsackie A9. Interact with RAB25.