The discoidin domain receptor family known as (cluster of differentiation is 167a) CD167a or DDR1, member 1, is a human gene. Receptor tyrosine kinases (RTK is) plays an important role in the transmission of cells in the microenvironment thereof. These molecules are involved in the regulation of metabolism cell proliferation and differentiation. is a RTK protein this gene encodes a wide, usually expressed in conversion epithelial cells, are activated by collagen types vary. This protein belongs to a subfamily of tyrosine kinase receptors with homology region of discoidin Dictyostelium discoideum protein I to the extracellular domain of them. The autophosphorylation can be achieved by (input to input VI I) collagen tested all previously. Kidney, lung, gastrointestinal tract, the brain showed the expression of the protein encoded by being limited to epithelial cells, especially in Northern blot analysis and study site. In addition, this protein is overexpressed in human tumors of specific brain child of breast, ovary, and esophagus, significantly. The transcript variants plurality of which is located on chromosome 6p21.3 near HLA class I. of several genes, this gene, alternative splicing of this gene results.
Receptor tyrosine kinases, play an important role in the transmission of cells in the microenvironment of them. These kinases have been implicated in the regulation of metabolism cell proliferation and differentiation. The protein gene is code belongs to the subfamily of tyrosine kinase receptors with bacteria yellow protein discoidin I viscosity homology in the extracellular region, and are activated by different types of collagen. Kidney, lung, gastrointestinal tract, the brain, the expression of this protein is restricted to epithelial cells. Furthermore, it is overexpressed in human tumors significantly constant is shown. Code alternatively spliced transcript variants various isoforms have been described for this gene.
Mammalian cells are constantly monitoring, in many cases, by the cell surface receptor, I will respond to the myriad of extracellular signals. Important two classes of cell surface receptors, including receptor tyrosine kinases which recognize peptide growth factors such as integrins that mediate binding of the components of the extracellular matrix most frequently and insulin. We, that was used as a ligand for a family of tyrosine kinase previous orphan discoidin domain-containing receptor-like collagen has been reported. The realization of the unexpected that can serve as a ligand for direct receptor tyrosine kinase and extracellular matrix molecules, and illustrates the receptor tyrosine kinase and integrin ligands common, their findings, cells in response to sensing the extracellular matrix It seems likely to change the view dominant mechanism that is high.
Protein tyrosine kinases (PTK), it is possible to play a role in the regulation of differentiated function of the thyroid cell growth and is involved in tumorigenesis types of papillary thyroid carcinoma. In order to better understand the role of PTK in the physiology and pathophysiology of the thyroid gland, we analyzed the expression profile of the receptor types RTC normal human thyroid tissue. Using degenerate oligonucleotide primers, highly conserved regions in the catalytic domain of the receptor type of PTK, has been amplified by RT-PCR. Sequencing of clone 100 were identified PTK novel not identify comprising non-receptor type 5 receptors and type 16, a PTK 21. Insulin-like growth factor I receptor, platelet-derived growth factor receptor, TrkE, an accelerator, and epidermal growth factors, many of which have no way, it is a thyroid that looks like of the most common types of RTK receptors in thyroid to be expressed has been shown. Expression of messenger RNA trkE for PDGFR, an accelerator in normal thyroid cells was confirmed by Northern blot analysis, interestingly, whereas expression levels of trkE mRNA and PDGFR, the cancer cell lines reduced in all three of the test thyroid is, mRNA and protein of the accelerator is overexpressed in thyroid cancer cell lines compared to three normal tissue. Axel gene, however, that both the amplified is also re-ordered. The biological activity of the ligand, then showed a modest mitogenic activity thyroid cancer overexpression accelerator and intracellular product accelerator, growth arrest-specific gene 6 was evaluated. Further, GAS6 mRNA is expressed in cells around it.
Thus, many of the likely to be involved in the regulation of thyroid cells identify RTK different expressed in thyroid here. The level of expression of RTK in cancer cells and normal that some failure or imbalance, thyroid cancer phosphorylation in the variable cells may be present is shown. Further, GAS6 have been identified as growth factors for the novel receptor tyrosine kinase overexpression accelerator thyroid carcinoma.
We identified discoidin domain receptor that defines an unusual class breast cancer tyrosine phosphorylated proteins, receptor tyrosine kinase (DDR). CDNA predicts a C-terminal domain of tyrosine kinases in the DDR, viscosity region of the N-terminal domain are similar to bacteria yellow lectin discoidin I. The proline / glycine hydrophilic extremely interrupted by transmembrane sequence predicted I have been associated with the rich domain. This extended proline / glycine-rich region may be required for a specific geometry of the interaction with ligand or substrate. Discoidin I domain, can be found in other proteins, including clotting factors VIII and V, which represents the class of the interaction domain and cell surface molecules specific.