Further, in order to form the integrin integrin αEβ7 intact molecules heteroaryl is a protein encoded by (ITGAE) Human ITGAE gene.CD103 E integrin known as cluster differentiation 103 (CD103), and binding integrin beta 7 (β7-ITGB7) However, there is no name for that particular. This term refers only αE chain strictly αEβ7 complex is referred to as “CD103” often. The β7 sub-group, please note that you can connect with the α4 and integrin α chain other.
CD103 is expressed widely in peripheral regulatory T cells, and some (such as γδT cells αβT cells) epithelial cells lymphocyteT. As well as being useful in determining the cell leukemia is a positive for this marker CD103 DCs.It, a subset of dendritic cells in the mucosa of the mesenteric lymph nodes and intestines in the expression of this marker stack-specific T-cell It has been reported, it is CD103-negative T-cell lymphoma than the gut associated known, unlike blood malignancies most other.
and adhesion molecule found in the epithelial cells, the main ligand for αEβ7 is E-cadherin. Important for the homing of T cells to the site of the intestine probably. Treg seems is important in reducing the immune response and play an important role in the prevention of autoimmune diseases. Treg’s, the cells are defined as CD4 and / CD25 / Foxp3. The cells of the CD4 / FoxP3 some, to express CD103, it is placed in the regulatory activities. The presence of CD103 in Treg cells above, this is unknown whether it represents a differentiated function or IEL T, for professional Treg of Treg cells
Now, research on CD103 function is filled with a mixed state. Like other integrins, and if you want to connect it, it provides stimulation of effector function and proliferation of T cells. This lymphocyte function-associated antigen (LFA) CD8 CTL-mediated effector function, between intercellular adhesion molecules (ICAM), the interaction between E-cadherin and CD103 is its be replaced by that is important. In many cases, this may be particularly important in epithelial target cells not ICAM-1. CD103 suggested that it may function as a homing receptor that promotes T cells to leach intestine. However, you can keep close to the epithelium clearly, rather than microlocalization T cell balance of evidence, in particular, it supports the role of the mucous membrane targeting. Unlike sister integrin α4β7 of CD103, can play an important role in the targeting of leukocytes to mucosal sites are known. Early studies of CD103-/ – significant changes only mouse is somewhat disappointing that the number of T-cell-dependent dermatitis of unknown etiology and mucosal T cells was modest decrease.
Maternal lymphocytes in fetal maternal interface play an important role in the immune acceptance of the allogeneic fetus. May include immunomodulatory properties are shown, omissions NK cells may be facilitated fetal trophoblast invasion of maternal tissue. More recently, the ability to inhibit the reaction of both nonspecific and specific fruits to concentrate in a short time CD4 CD25brigh. tFOXP3 Treg cell tissue is shown. CD8 T cells include, but are prime candidates for configuring the majority of T cells in fetomaternal interface, recognize and respond to the disparity of HLA fetal maternal. So far, there is limited information on the phenotype and function of CD8 T cell dropout during pregnancy. The phenotypic analysis of decidual CD8 T cells and peripheral blood, the presence of activated CD8 T cells, and was observed population CD8 cells and CD103 T short fabric. CD8 CD28 peripheral – unlike T cells, CD8 CD28-T cells dropped out, did not express cell lysis perforin molecule. Lack of perforin expression means to support the hypothesis shedding T cells that play a role in local immunomodulation and CD8 T cells can not give rise to decidual CD8 cytotoxic response. May result in placental pathological state to the impairment of fetal development and placental defects and regulations differentiation of transient CD8 T cells.
Joined on white CHS, the risk allele predetermined 7 SNP 74 was associated with an increased risk of the nominal stroke. Participants black, the risk allele predefined five SNP were associated with the nominal stroke. Val12Met SNP is associated with a stroke in participants in black and white of CHS in ABCG2. Kaplan-Meier estimates of the cumulative incidence of 10-year stroke, is greater among Val allele homozygotes compared to carriers of allele met participants of the black and white of CHS.
In white participants CHS, I increased the risk of stroke after adjustment was found that the risk allele of 7 SNP of 74 of these were associated (P <0.05) in nominal, risk factors traditional. There was and BAT2, ABCG2, MYH15, FSTL4, CALM1 HPS1, ITGAE the SNP of these seven. Risk factors for stroke range of from 1.49 to (allele) 1.15 further. The participation of black CHS, we found that after the risk allele SNP 5 was adjusted risk factors traditional nominally was associated (P <0.05) in the increased risk of stroke. Hazard ratio for SNP These five when adjusting the internal carotid artery intima and media atrial fibrillation further was 3.59.The risk estimates for the SNP 11 was associated with stroke from 1.40, thickness essentially unchanged or white, and black. Write table the relationship between SNP of all 74 cases and ischemic stroke, it is shown in the available online