EPH receptor A2 is a protein encoded by the gene of EphA2 (ephrin, type 2 receptor) in humans. This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. Usually, EPH subfamily receptors, have an extracellular region containing two fibronectin type III repeats and cysteine-rich domain and kinase domain of the single. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor. This gene encodes a protein that binds to ephrin ligand.

Intracellular signaling by receptor tyrosine kinases, regulate many aspects of cell behavior. Our laboratory and in Other recent studies, the receptor tyrosine kinase critical EphA2, the growth of tumor cells, to regulate the migration and invasiveness is shown. Result of intracellular signaling of EphA2 has become the focus of recent attention of biochemical changes induced by ligand-mediated activation of the EphA2 but most remain unknown. Here, it is shown to promote the phosphorylation of ERK kinase ligand stimulation of EphA2 nuclei followed by an increase in the induction of nuclear transcription factors Elk -1 and translocation. Ligand-mediated activation allows you to EphA2 to form a molecular complex with GRB2 and SHC adapter protein. Specifically, EphA2 tyrosine phosphorylation shows that reacted with PTB domains SH2 and the SHC. The interaction of the EphA2 with GRB2 suggest and to be mediated by SHC indirect, that this property is required for-mediated activation of the EphA2 kinase ERK. These studies, EphA2’s provides a new mechanism for showing how can convey information from the extracellular to the nucleus.

This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. Usually, EPH subfamily receptors, have an extracellular region containing two fibronectin type III repeats and cysteine-rich domain and kinase domain of the single. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor. This gene encodes a protein that binds to ephrin ligand. Mutations in this gene is responsible for hereditary several diseases associated with cataract.

This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. The receptor in EPH Subfamily has an extracellular region containing two fibronectin type III repeats and a cysteine-rich domain and the kinase domain of a single, typically. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor. The gene encoding this Protein that binds to ephrin ligand. Mutations in this gene is responsible for hereditary several diseases associated with cataract.

Receptor tyrosine kinase that binds the ligand family – membrane-bound ephrin present in the cell adjacent to the lead contact-dependent bidirectional signaling device in a cell adjacent to the random. The signaling path of the receptor in the downstream signaling of the first downstream, to the ephrin signaling pathway of Ligands are known as reverse signaling. Activation regulates the differentiation of cell migration, integrin-mediated adhesion, proliferation and by ephrin-A1/EFNA1 ligand. I adjust the signal transduction pathway (MAPK3/MAPK1 each) minutes of cell adhesion and by inhibition with DSG1/desmoglein-1 of ERK1/ERK2. You may also be involved in UV radiation-induced apoptosis, is a ligand-dependent stimulatory effect on migration chemotactic cells. During development, after patterning, it is possible to operate in a manner characteristic of fetal development several organizations. For example, is involved in branching morphogenesis during the development of the mammary gland and epidermal growth development and rebirth, the upper hindbrain. Commit ligand ephrin-A5/EFNA5, you can adjust the interaction of form and lens fiber cells, it is important for the development and maintenance of transparency of the lens. may play a role in bone remodeling by regulating osteoblast formation and osteoclast and ephrin-A2/EFNA2

Receptor tyrosine kinase EphA2. Receptor of the members of the ephrin family. Binds to ephrin-A1,-A3,-A4-A ​​5. Ephesians largest receptor tyrosine kinase family, in the tyrosine kinase group, has 14 members. They bind to the repulsive adhesion of cells to be place for membrane-anchored ligand, ephrin, of cell-cell contact, the establishment of a model of a mobile organization, the basis for the renovation and maintenance. EPH signal development, it is particularly important in the control of cell migration and cell adhesion of homeostasis and disease during axon guidance. EPHA receptors bind to ephrin ligands GPI anchor while bound to ephrin-B proteins with transmembrane and cytoplasmic domains are EPHB receptors. Interaction of ephrin-B proteins between the receptor kinase EPHB converts signaling cell types interaction both bidirectional signals. Adjust the adhesion of endothelial cells Eph receptors and ephrins and, it is necessary for the reconstruction of the vessel. The over-expressed in many cancers, including ovarian cancer aggressive, cervical cancer, lung cancer and breast cancer. Expression is correlated with the degree of growth of tumor xenografts angiogenesis, and metastasis. The soluble receptor inhibited angiogenesis and tumor growth in mice. Note: This description may include information from UniProtKB.

Biological process: development and germ-layer formation axis of the neural tube, growth-regulating protein kinase B signaling cascade of negative, activation of the GTP-ase of Rac, apoptosis, multicellular organisms, the formation of the notochord, the growth of mammary epithelial cells , regulate cell adhesion mediated control bone remodeling and vascular endothelial cell migration differentiation of osteoclasts, adjust, angiogenesis, differentiation of nerve cells, osteoblast differentiation, keratinocytes, by integrin, the development of notochord cells , ephrin receptor signaling pathway, protein kinase B signaling cascade, blood vessel formation, angiogenesis, cell adhesion, skeletal development