Integrin α-7 is a protein encoded by a gene ITGA7 in humans. ITGA7 is encoding the integrin α chain 7. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. To form the integrin that binds extracellular matrix proteins and laminin, prepared disulfide α chain 7 undergoes post-translational cleavage in the extracellular domain, by binding the heavy and light chains are bonded to R 1 was. Is expressed in differentiated cells, alpha 7 beta 1 is a major integrin complex. Is present in the mice, splice variants of alpha 7 different in both of the cytoplasmic domain and outside date only one type of transcript human Isolated in: respectively, and extracellular mouse corresponding to the variants B and X2 I include the cytoplasmic domain. It represents the minor species apparently biological significance is unknown, although the outer splice variants distinctive, was identified in humans.

Α7 integrin gene expression of (ITGA7) are regulated during the development of the formation of skeletal muscle. Increase in the production level and expression of isoforms, including the extracellular domain and cytoplasmic various, accompanied by muscle formation. Diversity of α7 basic structural gene of one or more associated with the development in the α chain, to determine by Southern blotting and whether examined the human genome and in situ hybridization rats we. Our results, I have shown that there is an α7 only one gene in the genome of both rat and human. ITGA7 to present on chromosome 12q13 in humans. Phylogenetic analysis of the sequence, the integrin α chain, in order to form the I-integrin, early gene integrin is an indication that you are in the Zu I-integrin and evolution methods. I-integrin alpha chain comprises a sequence of additional amino acids to about 180 due to the early introduction of non-I-gene. I-chain subfamily, evolution repeated further the same chromosome. No-I-integrin α chain gene is a local cluster of 17 and chromosome 2, 12, it matches the position of the human homeobox gene cluster closely. No-I-integrin α chain gene, appears to have evolved in the vicinity of the Hox cluster and parallel. Thus, cell-cell interactions in the end – Hox genes are fundamental to the design of integrin gene and the vehicle body, appears to have evolved in parallel inform matrix, coordinate fashion.

protein this gene encodes belong to the integrin α chain family. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. Cells and – – cells they mediate a wide range of matrix interactions, cell migration, morphological development, differentiation, and plays an important role in metastasis thereby. This protein acts as a receptor for membrane protein laminin. This can be skeletal muscle and is expressed in the heart mainly involved in the migration process and differentiation during myogenesis. Defects in this gene are associated with congenital myopathy. Code alternatively spliced ​​transcript variants have been marked for this gene different isoforms.

protein this gene encodes belong to the integrin α chain family. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. Cells and – Cell – They can mediate a wide range of matrix interactions, play an important role in cell migration, morphological development, and differentiation Thus, Transition. This protein acts as a receptor for membrane protein laminin. This can be skeletal muscle and is expressed in the heart mainly involved in the migration process and differentiation during myogenesis. Defects in this gene are associated with congenital myopathy. Code alternatively spliced ​​transcript variants have been marked for this gene different isoforms.
Alpha-7/beta-1 integrin is a major laminin receptor of adult muscle fibers and skeletal myoblasts. Between the muscle differentiation, it is possible to cause a change in mobility and the shape of the myoblasts to facilitate their positions in laminin-rich sites of the secondary fiber formation. Was to maintain the muscle fibers it Cellular architecture, and functional integrity and viability that attached. The Alpha-7X1B isolation and alpha-7X2B isoforms, is -1 2/4 and laminin myoblast laminin, laminin -1 activity to promote the transition of iso-alpha-7X1B is low. I will act as a Schwann cell receptor for laminin -2. And act as its effect and receptor-mediated COMP Vascular smooth muscle cell maturation (the VSMC) (similarity). Required to promote contraction obtain phenotype airway smooth muscle that is differentiated in (ASM) cells
Alpha-7/beta-1 integrin is a major laminin receptor of adult muscle fibers and skeletal myoblasts. Between the muscle differentiation, it is possible to cause a change in mobility and the shape of the myoblasts to facilitate their positions in laminin-rich sites of the secondary fiber formation. And their attachments muscle fibers cytoarchitecture was to survival and to maintain functional integrity it. Alpha-7X1B isolation and alpha-7X2B isoform, to facilitate the transition of -1 2/4 and laminin myoblast laminin, activity is low (in vitro) laminin-1 isoform alpha-7X1B. I will act as a Schwann cell receptor for laminin -2. Action to address the impact on (similarity) vascular smooth muscle cells and receptor-mediated senescence (the VSMC). This is necessary in order to facilitate the acquisition contraction phenotype airway smooth muscle that is differentiated in (ASM) cells.