Integrin alpha-11, a protein encoded by the gene ITGA11 in humans. This gene encodes the integrin α. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. I, the protein contains a domain that is displayed to dimer and 1 integrin beta in in vitro, and expressed in muscle tissues and bind collagen in this form. Thus, the protein may be involved in placement of the muscle tissue of the extracellular matrix. Alternate transcriptional splice variants have been found for this gene, its biological activity has not been determined. According to one study, to increase the front stroma cutting corneal button ITGA11 expression from affected keratoconic eye.

Is a large family of cell adhesion molecules consisting of a dimer αβ heterodimer was non-covalently bound integrin. Cloned, we decided to cDNA sequence specified novel human integrin α-subunit α11. DNA is included the I-domain of 207 residues α11, 1120 large linked to the cytoplasmic domain short transmembrane domain of 24 amino acids – the protein to mature with the extracellular domain of residues encoding. Putative protein α11, illustrate structural features typical of integrin α-subunit, I is similar to another group of collagen-binding integrin α-subunit. However, it is different from the integrin α chain most save cytoplasmic pattern GFFKR poorly. ITGA11 human gene is a q22.3-Q23 of 15 chromosome bands localized, rather than the transcript, and are found in various tissues, bone, cartilage, skeletal muscle and cardiac muscle primarily. 5,5 – expression of KBα11mRNA was detected in the small intestine.

This gene encodes the integrin α. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. I, the protein contains a domain that is displayed to dimer and 1 integrin beta in in vitro, and expressed in muscle tissues and bind collagen in this form. Thus, the protein may be involved in placement of the muscle tissue of the extracellular matrix. Alternate transcriptional splice variants have been found for this gene, its biological activity has not been determined.

This gene encodes the integrin α. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. I, the protein contains a domain that is displayed to dimer and 1 integrin beta in in vitro, and expressed in muscle tissues and bind collagen in this form. Thus, the protein may be involved in placement of the muscle tissue of the extracellular matrix. Alternate transcriptional splice variants have been found for this gene, its biological activity has not been determined.

Interactions of cancer cells with stromal plays an important role in chemotherapy-resistant tumor growth, invasion, metastasis, and angiogenesis. Factor for fibroblasts derived from or activated (CAF) fibroblasts associated with cancer, that through the paracrine secretion of growth factors probably contribute to the increased conversion of tumorigenicity epithelial cells and cancer cells possible. Recently, CAFS, to express higher levels α11 integrin was shown in NSCLC. One of the factors that are affected by a higher level of growth in ITGA11 of tumor, some IGF2. High levels of IGF2, can in turn, stimulate the growth of epithelial tumor cells leading to tumor growth and metastasis.

The lung cancer, is responsible for 1.3 million people second, all over the world, year the most common cancer in women to death in men. For (SCLC), non-small cell lung cancer (NSCLC) therapeutic purposes cause small-cell lung cancer the most common of death associated with, lung cancer can be classified into two main types. The last group is a disease of heterologous which can be classified into many types of the core 4 had squamous cell carcinoma adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, histologically. Adenocarcinoma is estimated that approximately one-third of the lung like the majority occur in peripheral lung tissue. In the Western world, most cases of adenocarcinoma are associated with smoking. However, among the people that has not been smoke, adenocarcinoma is the most common form of lung cancer. Expression was enhanced ITGA11 was reported in non-small cell carcinoma associated with the stromal fibroblasts. Possible involvement of α11 integrin has not been determined in other types of tumor stroma interactions.

The mature peptide, the length of the 145 kDa molecular weight) of α111166-amino acids by SDS-PAGE in (non-reducing conditions and is longer than is αE, and is composed of 1160 (preferred now identify integrin α-chain of other amino acid in the difference). Extracellular domain, includes repetition of 7 FG-GAP in the amino-terminal domain I insert between 2 and 3 repeat. Area comprises a metal ion-dependent adhesion site motif consists of amino acids 195 pcs booked. In addition to the metal chelate site I field, a divalent cation binding motifs three potential with the consensus sequence DXD / NXDXXXD presence in the 5-7 replicate. Cysteine ​​of 20 overall is located in the extracellular domain. Stored in the α1 chain and integrin α10 16 of them most closely related, they will be able to contribute to the intramolecular disulfide bond. We have added the amino acid sequence of 22 1 calf domain of stem region from amino acid 804 to 826, separated by integrin α chain of α11 other. The (1164 amino acids 1142) transmembrane domain is a 23 amino acids, the cytoplasmic tail of 24 amino acids follows. 10 Alpha – cytoplasmic tail is included GFFRS Save GFFKR sequence to discover instead of all other than the ITGA8 in α-chain sequence.