Ephrin type-B receptor 4 is a protein encoded by the EphB4 gene in humans. And its ligand ephrin receptor, ephrin, many processes of development of the nervous system in particular mediation,. Based on the sequence context and their structure, ephrins are divided into (EFNA) Class ephrin-A, which is fixed to the membrane by (EFNB) Class ephrin-B is a transmembrane protein and glycosylphosphatidylinositol linkage. Eph family of receptors are divided into two groups based on the similarity of their affinity for ephrin ligand binding and ephrin-AB extracellular domain sequence thereof. I comprises a subgroup of the maximum ephrin receptor tyrosine kinase (RTK) family. It is associated with ephrin-B2, protein this gene encodes plays an essential role in vascular development.

And its ligand ephrin receptor, ephrin, many processes of development of the nervous system in particular mediation,. Based on the sequence context and their structure, ephrins are divided into (EFNA) Class ephrin-A, which is fixed to the membrane by (EFNB) Class ephrin-B is a transmembrane protein and glycosylphosphatidylinositol linkage. Eph family of receptors are divided into two groups based on the similarity of their affinity for ephrin ligand binding and ephrin-AB extracellular domain sequence thereof. I comprises a subgroup of the maximum ephrin receptor tyrosine kinase (RTK) family. It is associated with ephrin-B2, protein this gene encodes plays an essential role in vascular development.

Rather than the expression in the arteries and veins in particular, ephrin-B4 is a transmembrane ligand is essential for the development of cardiovascular it. However, it is expressed in non-vascular tissue also ephrin-B2,, expressed in non-endothelial cell type and endothelial cells, it is interacting with the receptor class EPHB, more than one. Thus, these molecules and ephrin-B2, the identity of receptor (s) place dialogue for controlling angiogenesis is not clear. Here, specific receptors for EphB4, the ephrin-B2 of expressing the vein first indicates that it is expressed only in embryos and endothelial cells. And target mutations in the mutant phenotype replicate real EphB4 in ephrin-B2. These data are consistent with the idea bidirectional signaling that mediate suggesting that the interaction of ephrin-B2-EphB4 is higher in vascular endothelial cells essentially that is essential for blood vessel formation.

Receptor tyrosine kinase that binds to the ligand ephrin-B through a plurality of the contact-dependent bidirectional device adjacent cells, so that families present in the cells adjacent to each other. Downstream between signaling pathways ligand ephrin reverse signaling is called downstream signaling the first signaling path of the receptor. By adjusting the cell migration and cell adhesion and functional EFNB2 the cognate ligand / ligand together, plays a central role in angiogenesis and cardiac morphogenesis. Mediated EphB4 forward signaling controls the expression EFNB2 cell separation and cell shape rebound. It also plays vascular remodeling after birth, the role of permeability and morphogenesis, and why it is important in the context of tumor angiogenesis.

Angiogenesis is the growth of new blood vessels from pre-existing vessels. This is important for the development and growth of malignant tumors. Receptor tyrosine kinase EphB4 of which is expressed in epithelial many cancers are known to play an important role in angiogenesis.

We have developed two monoclonal antibodies against EphB4 etc. Krasnoperov is inhibited tumor growth and angiogenesis through a mechanism different two. By inducing the degradation of human and EphB4 (Please register angiogenesis) in the endothelial formation in vitro, MAb131 inhibits the growth of tumor in vivo. In contrast, not reduced, the mAb147 EphB4 of which inhibit tumor growth and angiogenesis, such as EphB4, but by the modulation of the vascular response to tumors probably EphB4. As a humanized version of these antibodies, the tumor suppressor function, They support the antibody against a strong candidate of EphB4 for clinical application.

Group Dr. Gill said, the path …. EphB4 antibody that describes the EphB4-specific monoclonal antibody to inhibit the formation and maturation to form blood vessels “new, to inhibit the growth of tumor in vivo of [S] novel Thus [They suggest that] the directed against. that may inhibit tumor growth via multiple mechanisms ”

Receptor monoclonal antibody anti-EphB4 This mouse is specific for EphB4 receptor in humans. Receptor monoclonal antibody of EphB4 recognizes the product of the gene expression of EphB4. Is expressed nervous system and includes a circulation system widely Eph receptor, during embryonic development. Receptor monoclonal antibody of EphB4 is the largest family of receptor tyrosine kinase. Approved applications for the receptor EphB4 monoclonal antibodies, was immunohistochemistry ELISA, Western blotting, and immunoprecipitation.