EPH receptor A5 (ephrin receptor type 5) is a protein of EphA5 encoded by genes in humans. This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. Usually, EPH subfamily receptors, have an extracellular region containing two fibronectin type III repeats and cysteine-rich domain and kinase domain of the single. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor.

This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. Usually, EPH subfamily receptors, have an extracellular region containing two fibronectin type III repeats and cysteine-rich domain and kinase domain of the single. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor. transcript variants encoding two different isoforms have been found for this gene.

Available receptors are known as Ephesians receptor. Eph family of receptors can be divided into two groups based on sequence of connecting the extracellular domain thereof. This group appears to match the functionality of the receptor that binds preferentially with ephrin-B protein and ephrin-A. Thus, ephrin – protein is called the group consisting of receptors that interact preferentially ephrin-B protein is called (pronounced the EDF-B) EPHB EPHA and (EDF-A pronunciation). Human gene map locus names have been proposed Group comprising receptors that interact preferentially with is EPHB, and EPHA respectively.

This gene belongs to the ephrin receptor subfamily of protein tyrosine kinase. In the central nervous system, EPH-related receptors EPH is involved in mediating a particular developmental event. The receptor in EPH Subfamily has an extracellular region containing two fibronectin type III repeats and a cysteine-rich domain and the kinase domain of a single, typically. Are divided into two groups based on the similarity of their affinity for the ligand ephrin binding and ephrin-AB extracellular domain sequence of the ephrin receptor. Transcript variants of two Isoforms with different encoding, have been found for this gene.

Adjacent contact Sohoko dependent signaling in the signaling path cells.The downstream of the receptor, and as a result, GPI anchor ephrin of multiple present in the cell in the adjacent – receptor tyrosine kinase family ligand binding, downstream signaling of the first called reverse signaling signal path between ephrin ligand is. Between function / cognate ligand for ligand, of EFNA5 EphA5 probably GPI-anchored ephrin. Has the potential to function as axon guidance molecules such during development, are involved in the development of retinal photoreceptor hippocamposeptal road cover, and entorhino-hippocampus. to play the role of synaptic plasticity in the adult brain by EFNA5 together even regulate synapse formation. In addition to its function in the nervous system, interaction with EFNA5 of EphA5 that mediates communication between the islet cells to modulate glucose-stimulated insulin secretion

Plays an important role in axonal guidance during development by receptor tyrosine kinases EphA5. However, the presence of proteins in the nervous system EphA5 has not been fully characterized. To investigate the mutant mice good localization EphA5 it is replaced with β-galactosidase, the cytoplasmic domain of EphA5, and assayed for temporal change region and both the distribution of proteins EphA5 in the nervous system and adult development. The embryonic development at the time, before the lid region, lid, cranial nerve nuclei, and were found in the spinal cord retina of the high level of protein of EphA5, olfactory bulb, neocortex, hippocampus, only. Is observed in succession intensity developed. Neocortex whereas got more strength, and to color the other areas of the midbrain and the cover lid before nuclear nuclear region, only the visual, it is spreading from the maturity date later. In adults, olfactory nucleus, neocortex, piriform cortex, induseum griseum, hippocampus, thalamus, amygdala, hypothalamus, and the receptor protein, continue to be found in a number of areas, including the septum. In addition, proteins EphA5 was found in axonal path of individual and striatum spot and barrel cortex CLAUSTRUM, streak demarcation, in the corpus callosum of the adult. We conclude that there is a possibility that the function of the EphA5 is not limited to the brain of the developing mouse, play a role in synaptic plasticity in adults.