CD49d is an integrin alpha subunit. It makes half of lymphocyte homing receptor α4β1. Product of the gene belongs to the family of integrin alpha chain protein. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. This gene encodes the α chain 4. I-domain also undergo cleavage disulfide bonds integrin alpha 4 is contained unlike other the α chain. Alpha associated with single or beta chain in β chain 7 4 chain.

Product of the gene belongs to the family of integrin alpha chain protein. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. This gene encodes the α chain 4. I-domain also undergo cleavage disulfide bonds integrin alpha 4 is contained unlike other the α chain. Alpha associated with single or beta chain in β chain 7 4 chain.

Embryogenesis of α4 integrin, hematopoiesis, heart development, and play an important role in the immune response. Because the α4 subunit regulates cellular functions different from the integrin subunits α other, perhaps, α4 integrin subunit, is required for biological processes such. Be coupled paxillin, an intracellular signaling adapter molecule firmly directly to the α4 cytoplasmic domain previously been reported, some of the abnormal functional response of α4 integrin-mediated cell adhesion, we reacted the account. In addition, it interferes with the α4-paxillin interaction, save 9 α4cytoplasmic domain is sufficient for Paki Shirin binding Tyr991within or reverse Glu983 this area is the effect of the α4 cytoplasmic domain – amino acid region and (Glu983-Tyr991), migration and cell proliferation discover the alanine substitution. In this study, mapped the use α4 binding site in paxillin mutation analysis, we examined the effect on the α4tail mediated functional response. That you are fully sequence between residues Asp275 and Ala176 of paxillin to connect to the queue α4 is reported. We targeted adhesion plaques, and found that it is possible to form a ternary complex queue α4, paxillin, fat, and pp125FAK α4-binding fragment Paki cylinder, P (Ala176-Asp275) is more efficient than in particular that it is blocking the paxillin binding to α4 tails manner combines block of FAT. In addition, α4 ​​tail paxillin suppresses be stimulated cell migration α4-binding fragment when expressed in cells. Thus, the binding paxillin increases in α4 tail, leading to suppression of α4-paxillin reaction block the α4-dependent cell response cell migration, selection.

Alpha-4/beta-7 and (VLA-4) integrin alpha-4/beta-1 is a receptor for fibronectin. They recognize one or more domains of the CS-5 domain of fibronectin alternative splicing and CS-1. They also, is a receptor for VCAM1. Integrin alpha-4/beta-1 recognizes the QIDS consecutive in VCAM1. Alpha-4/beta-7 integrin is a receptor for MADCAM1. It recognizes the sequence LDT of MADCAM1. Activated endothelial cells integrin VLA-4 led to the white blood cell line of VLA-4-positive aggregates most of the same type. It also is possible to participate in the interaction of cytolytic T cells and target cells

Integrin is expressed adhesion molecules ubiquitously. These are cell surface receptors present and hetero of α as β subunit. Under physiological conditions, integrins are contained ions Mg 2 or Ca 2 of which is essential for ligand binding glycosylation very. Integrin receptor binding extracellular matrix to (ECM), is important to the cell, which is achieved integrin by fibronectin. Interaction of laminin vitronectin, and collagen. I will form a complex with proteins, including integrin adhesion Tallinn in the cell, vinculin, and paxillin, and α-actin. They also, to mediate attachment to regulate the kinase, such as Src family kinase and focal adhesion kinase, the actin cytoskeleton. Integrins can be activate protein kinase that plays an important role in cell signaling are involved in the regulation of cell
Apoptosis growth, division, survival, differentiation, and migration. Glycoprotein II / IIIb group
Is an integrin receptor on the surface of platelets. We are involved in the crosslinking of platelets to fibrin, which plays an important role in thrombus formation.

hetero β subunit and α. α subunit, can be split into fragments of two non-covalently bind sometimes. 4 that are associated with, or α-or β-1, a β-7. α-4 interacts with the TGFB1I1/HIC5 PXN, and LPXN. Interact with CSPG4 in CSPG4 chondroitin sulfate glycosaminoglycan

Alpha-4/beta-7 and (VLA-4) ITGA4 alpha-4/beta-1 integrin is a receptor for fibronectin. They recognize one or more domains of the CS-5 domain of fibronectin alternative splicing and CS-1. They also, is a receptor for VCAM1. Alfa-4/beta-1 integrin recognizes the sequence QIDS in VCAM1. Alfa-4/beta-7 integrin is a receptor for MADCAM1. It recognizes the sequence LDT of MADCAM1. Activated endothelial cells integrin VLA-4 led to the white blood cell line of VLA-4-positive aggregates most of the same type. It also is possible to participate in the interaction of cytolytic T cells and target cells. hetero β subunit and α. α subunit, can be split into fragments of two non-covalently bind sometimes. 4 that are associated with, or α-or β-1, a β-7. α-4 interacts with the TGFB1I1/HIC5 PXN, and LPXN. Interact with CSPG4 in CSPG4 chondroitin sulfate glycosaminoglycan. I belong to the integrin α chain family. Note: This description may include information from UniProtKB.