Is a protein encoded by integrin α-5, by gene ITGA5 in humans. The product of this gene belongs to the integrin alpha chain family. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. This gene encodes the 5 integrin chain. Alpha circuit 5 was heavy and light chains were disulfide bond that is prepared is combined with R 1 to form a fibronectin receptor undergo post-translational cleavage of the extracellular domain. That in addition to the adhesive, is involved in signal transduction integrins to cell surface through is known.

Integrin cell – cell and cell – for heterodimeric complex and α related membrane receptor family involved in matrix interactions is a β subunit. To begin to understand the evolution of these complexes, we examined the genomic organization of the integrin β subunit and some α. In both the in situ hybridization and somatic cell hybrids, we vitronectin receptor (VNR a), the GPIIb the complex of platelet glycoprotein IIb group / IIIa fibronectin receptor (FNR a) is, α sub I have identified the chromosomal location of the unit of α-subunit gene. I was identified hetero of GPIIb / IIIa, the position on the chromosome of GPIIIa of β subunit gene, also. In our study, it can not find the locus of the α subunit is shown, each of which is located on chromosome different. Located in chromosome 17q21 —- 23 on GPIIb gene is located on chromosome 12q11 is located on chromosome 2, the gene of FNR with —- 13 gene for VNT. Unlike the chromosome of the alpha subunit gene of GPIIIa and GPIIb of, is located in chromosome 17q21 —- 23 and also is close to the dispersion GPIIIa gene physically. In these studies, GPIIIa and GPIIb for suggesting that genes integrin family of α subunits are scattered throughout the evolution during the close physical proximity. These two can be the physical proximity of GPIIIa and GPIIb of involved in co-expression of these proteins from megakaryocytes, limiting the use of polymorphism length limited to study the relationship between / the GPIIb can lead to linkage disequilibrium between genetic abnormalities IIIa small tribe.

The product of this gene belongs to the integrin alpha chain family. Integrin is a heterodimer integral membrane protein consisting of one α and β chain from the chain. This gene encodes the 5 integrin chain. Alpha circuit 5 was heavy and light chains were disulfide bond that is prepared is combined with R 1 to form a fibronectin receptor undergo post-translational cleavage of the extracellular domain. That in addition to the adhesive, is involved in signal transduction integrins to cell surface through is known.

Alpha-5/beta-1 integrin is a receptor for fibrinogen and fibronectin. This recognizes the RGD sequence in the ligand. In the case of HIV-1 infection, it appears interactions with extracellular viral Tat protein to enhance angiogenesis in Kaposi’s sarcoma lesions

Integrin is expressed adhesion molecules ubiquitously. These are cell surface receptors present and hetero of α as β subunit. Under physiological conditions, Mg2 ion of which is essential for ligand binding and CA2 and glycosyl strongly integrin is included. Integrin receptor binding extracellular matrix to (ECM), is important to the cell, which is achieved integrin by fibronectin

Interaction of laminin vitronectin, and collagen. I will form a complex with proteins, including integrin adhesion Tallinn in the cell, vinculin, and paxillin, and α-actin. They also, to mediate attachment to regulate the kinase, such as Src family kinase and focal adhesion kinase, the actin cytoskeleton. Integrins can be activate protein kinase that plays an important role in cell signaling are involved in the regulation of cell.

Apoptosis growth, division, survival, differentiation, and migration. Glycoprotein II / IIIb group
Is an integrin receptor on the surface of platelets. We are involved in the crosslinking of platelets to fibrin, which plays an important role in thrombus formation.

hetero β subunit and α. α subunit is composed of a light chain and a binding heavy chain by a disulfide bond. It is associated with alpha 5 beta 1. Interact with NISCH and HPS5. I will interact with and address RAB21. Reaction and Tat of HIV-1