Integrin alpha 6 is a protein encoded by a gene ITGA6 in humans. Integrin α chain, is alpha 6 ITGA6 protein product. Integrin is a cell surface protein of integrated consisting of one α and β chain from the chain. Chain can be combined with different partners on the results of various integrins. For example, β4 integrin May 6 in combination or TSP180, and many β-1 integrin VLA-6. Integrin to be involved in signal transduction to the cell surface through cell adhesion and are known. transcript variants encoding two different isoforms have been found for this gene.

Integrin α chain, is alpha 6 ITGA6 protein product. Integrin is a cell surface protein of integrated consisting of one α and β chain from the chain. Chain can be combined with different partners on the results of various integrins. For example, β4 integrin May 6 in combination or TSP180, and many β-1 integrin VLA-6. Integrin to be involved in signal transduction to the cell surface through cell adhesion and are known. transcript variants encoding two different isoforms have been found for this gene.

Through-4 superfamily (TM4SF) protein forms a complex with cell surface proteins and other integrins. Immunoprecipitated with CD81 from MDA-MB-435 cancer cells of the breast for further characterization of the major protein present in TM4SF protein complex in a typical combined monoclonal antibodies to both proteins. Only two types of cell surface proteins that are recognized by antibodies that are 35 our choice. These included (NAG-2 and CD9, CD63,) protein TM4SF three different and (α6β1) integrin. NAG-2 protein (novelantigen-2), which is up to a cell surface protein of 30 kDa unknown. To isolate NAG-2 by using the protocol of cDNA encoding for expression cloning. The deduced amino acid sequence TM4SF, the NAG-2 showed maximum identity for CD53 (34%) when aligned with other proteins. Immunohistochemistry flow cytometry and Northern blotting showed to be present in a variety of cell types NAG-2 and the tissue, brain, lymphocytes, and not present in platelets. the organization in a different, strong staining was observed in fibroblasts, endothelial cells, in mesothelial cells and follicular dendritic cells. as nonstringent preparation, (CD81 and CD9), and NAG-2 protein was co-immunoprecipitated with integrin (α3β1andα6β1) members TM4SF other. In addition, immunofluorescence two color was shown to co-localize NAG-2 and CD81 on the surface of the growth of HT1080 cells. These results confirm the presence of TM4SF integrin complex with NAG-2-specific TM4SF · TM4SF.

Alpha-6/beta-1 integrin is a receptor on platelets laminin. Is a receptor for laminin in epithelial cells, integrin alpha-6/beta-4 is an alpha 6 integrin α chain, which plays an important role in the structural hemidesmosome.The ITGA6 protein production. Integrin is a cell surface protein of integrated consisting of one α and β chain from the chain. Chain can be combined with different partners on the results of various integrins. For example, β4 integrin May 6 in combination or TSP180, and many β-1 integrin VLA-6. Integrin to be involved in signal transduction to the cell surface through cell adhesion and are known. transcript variants encoding two different isoforms have been found for this gene.

ITGA6 gene provides instructions for making (α6 division) of the two proteins called integrins α6β1 and integrin α6β4. The integrin molecules of the other groups of proteins that control the adhesion of cells to each other, and protein (cell adhesion) – a web around the (cell matrix adhesion). Integrins transmits chemical signals that regulate cell growth and activity of specific genes.

protein is located in the epithelial cells, which are cells that line the surface of the body cavity mainly to α6β4 integrin. This protein plays a particularly important role in stabilizing and strengthening the skin. This is part of hemidesmosomes, is a microscopic structure for fixing the outer layer of skin (epidermis) to the lower layer. As part of a complex network of protein hemidesmosomes, α6β4 integrin, helps to keep the skin layer.
Made integrin subunits other forming the tissue or organ before birth α6, with α6β1 integrin function. α6β1 integrin protein is not considered as α6β4 integrin as well.

5 mutation was found to cause epidermolysis bullosa with pyloric atresia (EB-PA) at least the gene ITGA6. In addition, people with blistering of the skin, the EB-PA is born with a lethal blockage of the digestive tract called pyloric atresia. Mutations in the gene ITGA6 accounts for about 5% of all cases of EB-PA.  Can lead to loss of α6β4 integrin function ITGA6 of cause gene mutations in EB-PA. These mutations alter the structure and function of normal cells, preventing or α6 integrin subunits to produce enough of this subset. cause the cells of the epidermis result lack of α6β4 integrin function is fragile, as fragile. Minor trauma other, can result in the formation of extensive blister, and to separate the skin layer or friction. How ITGA6 mutation is associated with pyloric atresia in the gene it is not so clear.

I believe that researchers, and may play a decisive role in the development of malignant tumors of both α6β4 integrin and α6β1 integrin is called a cancer. These arise in epithelial cells, these cancers can be breast cancer, lung cancer, liver cancer, prostate cancer, and may affect the organs and many tissues, including the skin. Changes in α6β4 integrin α6β1 integrin activities and places and cancer cells is associated with the development of cancer. Integrin protein, to activate the major signaling molecules to move through the body and invade other tissues, causing the cancer cells. These signals, the cancer cells to self-destruct, so that there is more resistant. Recent studies, in addition to their role in the evolution of cancers existing show integrin α6β1, α6β4 integrin, that it is possible and included in the initial formation of these tumors.