CD49b is a protein encoded by a gene in human CD49b. CD49b protein is α integrin subunit. This makes the α2β1 integrin half duplex. Integrin is a hetero integral membrane glycoprotein composed from a common β chain of the single α chain. These are various T cells (NKT cells on), cell types, including platelets NK cells, and fibroblasts. It is involved in cell adhesion, integrin have joined the mediated signaling on the cell surface. DX5 is a monoclonal antibody that binds specifically to CD49b.

This gene encodes a transmembrane receptors for collagen and related proteins the α subunits. The encoded protein forms a heterodimer with the β subunit I mediates the adhesion of other cells and platelets in the extracellular matrix. Loss of the encoded protein is associated with bleeding disorders, platelet-type 9. Antibodies against this protein have been found in immune disorders, including some neonatal thrombocytopenia platelets. This gene is located in close proximity to the gene associated with the α subunit. Result of alternative splicing in the transfer multiple variants.

From all strains of mice, DX5 monoclonal antibody is a useful reagent for inspection it is dirty NK cells. The retrovirus-mediated expression cloning system, we have identified a DX5 molecules recognized by monoclonal antibodies. DNA 5 KB of which encodes a protein that reacts with the monoclonal antibody DX5 was the same (2 silver, late integrin α2 very) and CD49b this molecule and, isolated from NK cell cDNA library. Reacts with the transformant expressing CD49b in DX5 monoclonal antibody, the binding of transfectants and NK-DX5 cells was blocked in the presence of anti-CD49b mAb other CD49b. The NK1.1 When cultured in IL-2, NK cells, they lose reactivity with the result of gradual monoclonal antibody DX5 cell proliferation. It was significantly higher cytotoxicity mediated by DX5 NK cells when compared to DX5-NK cells. Therefore, DX5 monoclonal antibodies may be used in order to recognize CD49b, to determine the subset of functionally distinct NK cells.

Integrin alpha-2/beta-1 is a receptor for E-cadherin laminin, collagen, collagen C-propeptides, and fibronectin. It proline in collagen – recognizes the hydroxyl sequence GFPGER. It is responsible for the adhesion of other cells and platelets in the regulation of organization of extracellular matrix which is synthesized de novo expression and collagenase gene force collagen, collagen

This gene encodes a transmembrane receptors for collagen and related proteins the α subunits. The encoded protein forms a heterodimer with the β subunit I mediates the adhesion of other cells and platelets in the extracellular matrix. Loss of the encoded protein is associated with bleeding disorders, platelet-type 9. Antibodies against this protein have been found in immune disorders, including some neonatal thrombocytopenia platelets. This gene is located in close proximity to the gene associated with the α subunit. Result of alternative splicing in the transfer multiple variants.

hetero β subunit and α. I have been associated with the alpha 2 beta 1. Interact with RAB21 and HPS5. Bound to 8 and 1 capsid protein to echo human viruses, I will function as a receptor for these viruses. It acts on each other (via ITAG2 I-domain) and rotavirus VP4, this interaction occurs only in rotavirus strain ITGA2 of integrin dependent
Function as a receptor

ITGA2 alpha-2/beta-1 integrin is a receptor of the E-cadherin laminin, collagen, collagen C-propeptide, and fibronectin. It proline in collagen – recognizes the hydroxyl sequence GFPGER. It is responsible for the adhesion of other cells and platelets to collagen, which regulate the expression of the organization of the extracellular matrix to the power generation of the collagenase gene and collagen newly synthesized. I belong to the integrin α chain family. Note: This description may include information from UniProtKB.